UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 13D
Under the Securities Exchange Act of 1934
(Amendment No. 1)
ACRIVON THERAPEUTICS, INC.
(Name of Issuer)
Common Stock, par value $0.001 per share
(Title of Class of Securities)
004890109
(CUSIP Number)
RA Capital Management, L.P.
200 Berkeley Street, 18th Floor
Boston, MA 02116
Telephone: 617.778.2500
Attn: Peter Kolchinsky
(Name, Address and Telephone Number of Person Authorized
to
Receive Notices and Communications)
March 28, 2023
(Date of Event Which Requires Filing of this Statement)
If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box. ¨
Note: Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See Rule 13d-7 for other parties to whom copies are to be sent.
* The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.
The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).
CUSIP No. 004890109
| 1 |
Names of Reporting Persons.
RA Capital Management, L.P.
| |
| 2 | Check the Appropriate Box if a Member of a Group (See Instructions) | |
| (a) ¨ | ||
| (b) ¨ | ||
| 3 | SEC Use Only | |
| 4 |
Source of Funds (See Instructions): AF | |
| 5 |
Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e): ¨ | |
| 6 |
Citizenship or Place of Organization. Delaware | |
|
Number of Shares Beneficially Owned by Each Reporting Person With |
7 Sole Voting Power 0 shares
| |
|
8 Shared Voting Power 4,817,359 shares
| ||
|
9 Sole Dispositive Power 0 shares
| ||
|
10 Shared Dispositive Power 4,817,359 shares
| ||
| 11 |
Aggregate Amount Beneficially Owned by Each Reporting Person 4,817,359 shares |
|
| 12 | Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions) ¨ | |
| 13 |
Percent of Class Represented by Amount in Row (11) 22%1 |
|
| 14 |
Type of Reporting Person (See Instructions) IA, PN
|
|
1 The Reporting Person is the beneficial owner of 4,810,508 shares of the Issuer’s Common Stock as well as conversion shares underlying each of 4,894 vested stock options (right to buy) and 1,957 stock options (right to buy) which will vest within 60 days held by Dr. Derek DiRocco for the benefit of RA Capital. The percentage calculation assumes that there are 21,927,485 outstanding shares of Common Stock of the Issuer, based on 21,920,634 outstanding shares of Common Stock of the Issuer based on the Issuer’s Form 10-K filed with Securities and Exchange Commission (“SEC”) on March 28, 2023, and giving effect to stock options referenced herein.
CUSIP No. 004890109
| 1 |
Names of Reporting Persons.
Peter Kolchinsky
| |
| 2 | Check the Appropriate Box if a Member of a Group (See Instructions) | |
| (a) ¨ | ||
| (b) ¨ | ||
| 3 | SEC Use Only | |
| 4 |
Source of Funds (See Instructions): AF | |
| 5 |
Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e): ¨ | |
| 6 |
Citizenship or Place of Organization. United States | |
|
Number of Shares Beneficially Owned by Each Reporting Person With |
7 Sole Voting Power 0 shares
| |
|
8 Shared Voting Power 4,817,359 shares
| ||
|
9 Sole Dispositive Power 0 shares
| ||
|
10 Shared Dispositive Power 4,817,359 shares
| ||
| 11 |
Aggregate Amount Beneficially Owned by Each Reporting Person 4,817,359 shares |
|
| 12 | Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions) ¨ | |
| 13 |
Percent of Class Represented by Amount in Row (11) 22%2 |
|
| 14 |
Type of Reporting Person (See Instructions) HC, IN
|
|
2 The Reporting Person is the beneficial owner of 4,810,508 shares of the Issuer’s Common Stock as well as conversion shares underlying each of 4,894 vested stock options (right to buy) and 1,957 stock options (right to buy) which will vest within 60 days held by Dr. Derek DiRocco for the benefit of RA Capital. The percentage calculation assumes that there are 21,927,485 outstanding shares of Common Stock of the Issuer, based on 21,920,634 outstanding shares of Common Stock of the Issuer based on the Issuer’s Form 10-K filed with Securities and Exchange Commission (“SEC”) on March 28, 2023, and giving effect to stock options referenced herein.
CUSIP No. 004890109
| 1 |
Names of Reporting Persons.
Rajeev Shah
| |
| 2 | Check the Appropriate Box if a Member of a Group (See Instructions) | |
| (a) ¨ | ||
| (b) ¨ | ||
| 3 | SEC Use Only | |
| 4 |
Source of Funds (See Instructions): AF | |
| 5 |
Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e): ¨ | |
| 6 |
Citizenship or Place of Organization. United States | |
|
Number of Shares Beneficially Owned by Each Reporting Person With |
7 Sole Voting Power 0 shares
| |
|
8 Shared Voting Power 4,817,359 shares
| ||
|
9 Sole Dispositive Power 0 shares
| ||
|
10 Shared Dispositive Power 4,817,359 shares
| ||
| 11 |
Aggregate Amount Beneficially Owned by Each Reporting Person 4,817,359 shares |
|
| 12 | Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions) ¨ | |
| 13 |
Percent of Class Represented by Amount in Row (11) 22%3 |
|
| 14 |
Type of Reporting Person (See Instructions) HC, IN
|
|
3 The Reporting Person is the beneficial owner of 4,810,508 shares of the Issuer’s Common Stock as well as conversion shares underlying each of 4,894 vested stock options (right to buy) and 1,957 stock options (right to buy) which will vest within 60 days held by Dr. Derek DiRocco for the benefit of RA Capital. The percentage calculation assumes that there are 21,927,485 outstanding shares of Common Stock of the Issuer, based on 21,920,634 outstanding shares of Common Stock of the Issuer based on the Issuer’s Form 10-K filed with Securities and Exchange Commission (“SEC”) on March 28, 2023, and giving effect to stock options referenced herein.
CUSIP No. 004890109
| 1 |
Names of Reporting Persons.
RA Capital Healthcare Fund, L.P.
| |
| 2 | Check the Appropriate Box if a Member of a Group (See Instructions) | |
| (a) ¨ | ||
| (b) ¨ | ||
| 3 | SEC Use Only | |
| 4 |
Source of Funds (See Instructions): WC | |
| 5 |
Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e): ¨ | |
| 6 |
Citizenship or Place of Organization. United States | |
|
Number of Shares Beneficially Owned by Each Reporting Person With |
7 Sole Voting Power 0 shares
| |
|
8 Shared Voting Power 4,384,206 shares
| ||
|
9 Sole Dispositive Power 0 shares
| ||
|
10 Shared Dispositive Power 4,384,206 shares
| ||
| 11 |
Aggregate Amount Beneficially Owned by Each Reporting Person 4,384,206 shares |
|
| 12 | Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions) ¨ | |
| 13 |
Percent of Class Represented by Amount in Row (11) 20%4 |
|
| 14 |
Type of Reporting Person (See Instructions) PN
|
|
4 The Reporting Person is the beneficial owner of 4,384,206 shares of the Issuer’s Common Stock. The percentage calculation assumes that there are 21,927,485 outstanding shares of Common Stock of the Issuer, based on 21,920,634 outstanding shares of Common Stock of the Issuer based on the Issuer’s Form 10-K filed with Securities and Exchange Commission (“SEC”) on March 28, 2023, and giving effect to stock options referenced herein.
Cusip No. 004890109
SCHEDULE 13D
Item 1. Security and Issuer
Item 1 of the Statement is amended and supplemented as follows:
This Amendment No. 1 amends and supplements the statement on Schedule 13D originally filed with the Securities and Exchange Commission (the “SEC”) on November 28, 2022 (the “Statement”), by the Reporting Persons with respect to the common stock, $0.001 par value per share (the “Common Stock”), of Acrivon Therapeutics, Inc., a Delaware corporation (the “Issuer”), which has its principal executive offices at 480 Arsenal Way, Suite 100, Watertown, MA. Unless otherwise defined herein, capitalized terms used in this Amendment No. 1 shall have the meanings ascribed to them in the Statement. Unless amended or supplemented below, the information in the Statement remains unchanged.
Item 2. Identity and Background
Item 2 of the Statement is amended and restated as follows:
(a) This Statement is being filed on behalf of RA Capital Management, L.P. (” RA Capital”), RA Capital Healthcare Fund, L.P. (the “Fund”), Peter Kolchinsky, and Rajeev Shah. RA Capital, Dr. Kolchinsky, Mr. Shah, and the Fund are collectively referred to herein as the “Reporting Persons.”
The Reporting Persons ownership of the Issuer’s securities includes (1) 4,384,206 Common Stock shares held directly by the Fund, (2) 426,302 Common Stock shares held directly by the RA Capital Nexus Fund II, L.P (the “Nexus Fund II”), (3) a total of 4,894 vested stock options (right to buy), and (4) 1,957 stock options (right to buy) which shall vest within 60 days of this filing.
RA Capital Healthcare Fund GP, LLC is the general partner of the Fund and RA Capital Nexus Fund II GP, LLC is the general partner of the Nexus Fund II. The general partner of RA Capital is RA Capital Management GP, LLC, of which Dr. Kolchinsky and Mr. Shah are the controlling persons. RA Capital serves as investment adviser for the Fund and the Nexus Fund II and may be deemed a beneficial owner, for purposes of Section 13(d) of the Securities Exchange Act of 1934 (the “Act”), of any securities of the Issuer held by the Fund or the Nexus Fund II. The Fund and the Nexus Fund II have delegated to RA Capital the sole power to vote and the sole power to dispose of all securities held in the Fund’s and the Nexus Fund II’s portfolio, including the shares of the Issuer’s Common Stock reported herein. Because the Fund and the Nexus Fund II have divested themselves of voting and investment power over the reported securities they hold and may not revoke that delegation on less than 61 days’ notice, the Fund and the Nexus Fund II disclaim beneficial ownership of the securities they hold for purposes of Section 13(d) of the Act and therefore disclaim any obligation to report ownership of the reported securities under Section 13(d) of the Act. As managers of RA Capital, Dr. Kolchinsky and Mr. Shah may be deemed beneficial owners, for purposes of Section 13(d) of the Act, of any securities of the Issuer beneficially owned by RA Capital. RA Capital, Dr. Kolchinsky, and Mr. Shah disclaim beneficial ownership of the securities reported in this Schedule 13D Statement (the “Statement”) other than for the purpose of determining their obligations under Section 13(d) of the Act, and the filing of this 13D/A shall not be deemed an admission that either RA Capital, Dr. Kolchinsky, or Mr. Shah is the beneficial owner of such securities for any other purpose.
(b) The address of the principal business office of each of the Reporting Persons is 200 Berkeley Street, 18th Floor, Boston, MA 02116.
Cusip No. 004890109
(c) The Fund is a private investment vehicle. RA Capital provides investment management services to the Fund and the Nexus Fund II. The principal occupation of Dr. Kolchinsky and Mr. Shah is investment management.
(d) During the last five years, none of the Reporting Persons has been convicted in a criminal proceeding (excluding traffic violations or similar misdemeanors).
(e) During the last five years, none of the Reporting Persons has been a party to a civil proceeding of a judicial or administrative body of competent jurisdiction and as a result of such proceeding was or is subject to a judgment, decree of final order enjoining future violations of, or prohibiting or mandating activities subject to, federal or state securities laws or finding any violation with respect to such laws.
(f) See Item 6 of the cover pages.
Item 5. Interest in Securities of the Issuer
Item 5 of the Statement is amended and supplemented as follows:
(a) and (b) See Items 7-11 of the cover pages above and Item 2.
(c) The following table lists the Reporting Persons’ transactions in Common Stock that were effected during the sixty day period prior to the filing of this Schedule 13D:
| Transaction | Purchaser | Date | No. Shares | Price | ||||||||||
| Vest Stock Option (Right to Buy) | RA Capital | 12-Feb-2023 | 978.75 | (1 | ) | |||||||||
| Vest Stock Option (Right to Buy) | RA Capital | 12-Mar-2023 | 978.75 | (1 | ) | |||||||||
| Vest Stock Option (Right to Buy) | RA Capital | 12-April-2023 | 978.75 | (1 | )* | |||||||||
| Vest Stock Option (Right to Buy) | RA Capital | 12-May-2023 | 978.75 | (1 | )* | |||||||||
| (1) | This option represents a right to purchase a total of 35,235 shares of the Issuer’s Common Stock, which began vesting on October 12, 2022 in 36 equal monthly installments over three years, subject to Dr. DiRocco’s continued service to the Issuer through each vesting date. These options have an exercise price of $12.50 |
* Represents future vesting within 60 days from the filing date of this Schedule 13D.
(d) Not applicable.
(e) Not applicable.
Cusip No. 004890109
Item 7. Material to Be Filed as Exhibits
Item 7 of the Statement is amended and supplemented by the following:
| Exhibit 1 | Joint Filing Agreement |
Cusip No. 004890109
SIGNATURE
After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.
Date: March 30, 2023
| RA CAPITAL MANAGEMENT, L.P. | |||
| By: | /s/ Peter Kolchinsky | ||
| Name: | Peter Kolchinsky | ||
| Title: | Authorized Signatory | ||
| PETER KOLCHINSKY | |||
| /s/ Peter Kolchinsky | |||
| RAJEEV SHAH | |||
| /s/ Rajeev Shah | |||
| RA CAPITAL HEALTHCARE FUND, L.P. | |||
| By: | RA Capital Healthcare Fund GP, LLC | ||
| Its: | General Partner | ||
| By: | /s/ Peter Kolchinsky | ||
| Name: | Peter Kolchinsky | ||
| Title: | Manager | ||
Cusip No. 004890109
JOINT FILING AGREEMENT
This Joint Filing Agreement, dated as of March 30, 2023, is by and among RA Capital Management, L.P., Peter Kolchinsky, Rajeev Shah, and RA Capital Healthcare Fund, L.P. (the foregoing are collectively referred to herein as the “Filers”).
Each of the Filers may be required to file with the United States Securities and Exchange Commission a statement on Schedule 13G and/or 13D with respect to Common Stock, par value $0.001 per share of Acrivon Therapeutics, Inc. beneficially owned by them from time to time.
Pursuant to and in accordance with Rule 13(d)(1)(k) promulgated under the Securities Exchange Act of 1934, as amended, the Filers hereby agree to file a single statement on Schedule 13G and/or 13D (and any amendments thereto) on behalf of each of such parties, and hereby further agree to file this Joint Filing Agreement as an exhibit to such statement, as required by such rule.
This Joint Filing Agreement may be terminated by any of the Filers upon one week’s prior written notice or such lesser period of notice as the Filers may mutually agree.
Executed and delivered as of the date first above written.
| RA CAPITAL MANAGEMENT, L.P. | |||
| By: | /s/ Peter Kolchinsky | ||
| Name: | Peter Kolchinsky | ||
| Title: | Authorized Signatory | ||
| PETER KOLCHINSKY | |||
| /s/ Peter Kolchinsky | |||
| RAJEEV SHAH | |||
| /s/ Rajeev Shah | |||
| RA CAPITAL HEALTHCARE FUND, L.P. | |||
| By: | RA Capital Healthcare Fund GP, LLC | ||
| Its: | General Partner | ||
| By: | /s/ Peter Kolchinsky | ||
| Name: | Peter Kolchinsky | ||
| Title: | Manager | ||